Prenatal drug exposure and neurodevelopmental programming of glucocorticoid signalling
نویسندگان
چکیده
منابع مشابه
Prenatal cocaine exposure and prematurity: neurodevelopmental growth.
The consequences of prematurity and prenatal cocaine exposure on early neurobehavior and physical growth were examined longitudinally in a sample of 20 cocaine-exposed and 20 non-exposed preterm neonates. The magnitude of the difference in physical growth acceleration related to prenatal cocaine exposure increased with increasing birth gestational age, whereas growth rate differences in irritab...
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Our aim was to determine the postnatal effects of single and repeated glucocorticoid injections during late gestation. Repeated (104, 111, 118, 125 days) or single (104 days) injections of betamethasone or saline were given to the ewe or by ultrasound guided injection to the fetus (term 150 days). Lambs were born spontaneously and studied at 3 and 6 mo and 1 yr of age. Arterial pressure was mea...
متن کاملNeuroimaging of prenatal drug exposure.
a Department of Physiology and Pharmacology, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Box #29, Brooklyn, NY 11203, USA b Medical Department, Brookhaven National Laboratory, New York, USA c University of Florida, College of Medicine, Department of Pediatrics, Gainesville, Florida, USA d University of Miami School of Medicine, Department of Pediatrics, Miami, Fl...
متن کاملPrenatal glucocorticoid exposure in rats: programming effects on stress reactivity and cognition in adult offspring.
Human epidemiological studies have provided compelling evidence that prenatal exposure to stress is associated with significantly increased risks of developing psychiatric disorders in adulthood. Exposure to excessive maternal glucocorticoids may underlie this fetal programming effect. In the current study, we assessed how prenatal dexamethasone administration during the last week of gestation ...
متن کاملProgramming Effects of Prenatal Glucocorticoid Exposure with a Postnatal High-Fat Diet in Diabetes Mellitus
Increasing evidence has shown that many chronic diseases originate from early life, even before birth, through what are termed as fetal programming effects. Glucocorticoids are frequently used prenatally to accelerate the maturation of the lungs of premature infants. High-fat diets are associated with insulin resistance, but the effects of prenatal glucocorticoid exposure plus a postnatal high-...
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ژورنال
عنوان ژورنال: Journal of Neuroendocrinology
سال: 2019
ISSN: 0953-8194,1365-2826
DOI: 10.1111/jne.12786